1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Names and Identifiers

Name	Doxapram Hydrochloride
Synonyms	Dopram Stimulexin Doxapram hcl UNII-P5RU6UOQ5Y Doxapram Hydrochloride DOXAPRAMHYDROCHLORIDE,ANHYDROUS DOTHIEPINHYDROCHLORIDE,ANHYDROUS Doxapram hydrochloride anhydrous 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidone hydrochloride 1-Ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-2-pyrrolidinone hydrochloride 3,3-Diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone hydrochloride 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenylpyrrolidin-2-one hydrochloride 1-ethyl-4-(2-morpholin-4-ylethyl)-3,3-diphenyl-pyrrolidin-2-one hydrochloride 4-[2-(1-Ethyl-5-oxo-4,4-diphenyl-3-pyrolidinyl)ethyl]morpholine·hydrochloride 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, monohydrochloride 2-Pyrrolidinone, 1-ethyl-4-(2-morpholinoethyl)-3,3-diphenyl-, hydrochloride (7CI) 2-Pyrrolidinone, 1-ethyl-4-(2-(4-morpholinyl)ethyl)-3,3-diphenyl-, monohydrochloride
CAS	113-07-5
EINECS	204-022-3
InChI	InChI=1/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Physico-chemical Properties

Molecular Formula	C24H31ClN2O2
Molar Mass	414.96814
Boling Point	536.4°C at 760 mmHg
Flash Point	278.2°C
Vapor Presure	1.4E-11mmHg at 25°C
Storage Condition	Sealed in dry,Room Temperature

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Risk and Safety

UN IDs	3249
Hazard Class	6.1(b)
Packing Group	III

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Standard

Authoritative Data Verified Data

This product is (±) 1-ethyl -3, 3-monophenyl-4-(2-morenyl ethyl)-2-pyrrolidone hydrochloride monohydrate. The content of C24H30N202 • HC1 shall be between 98.0% and 100.5% based on the dry product.

Last Update：2024-01-02 23:10:35

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Trait

Authoritative Data Verified Data

This product is white or off-white crystalline powder; Odorless.
This product is slightly soluble in water, chloroform or ethanol, and insoluble in ether.

melting point

The melting point of this product (General 0612) is 217~221°C.

Last Update：2022-01-01 15:03:44

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Differential diagnosis

Authoritative Data Verified Data

take this product, add water to dissolve and make a solution containing about 0.4mg per lml, according to UV-visible spectrophotometry (General rule 0401), at 252nm, there is a maximum absorption at the wavelength of 258nm and 264nm, and a minimum absorption at the wavelength of 244nm, 254nm and 262nm.
The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 643).
This product is chloride identification reaction (General 0301).

Last Update：2022-01-01 15:03:45

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Exam

Authoritative Data Verified Data

acidity

take 0.50g of this product, add 50ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 3.5~5.0.

clarity and color of solution

take this product l.Og, add water 50ml dissolved, the solution should be clear and colorless.

Related substances

take an appropriate amount of this product, add water to dissolve and dilute to make a solution containing about 1 mg per 1 ml, as a test solution; Take an appropriate amount of precision, A solution containing about 2ug per 1 ml was prepared as a control solution by quantitative dilution with water. According to the test of high performance liquid chromatography (General 0512), silica gel bonded with a Eighteen alkyl silane was used as a filler (end-capped column). Olmol/L sodium acetate solution (adjusted to pH 4.5 with glacial acetic acid)-acetonitrile (70:30) as mobile phase, the detection wavelength was 214nm. l0ul of the test solution and the control solution were respectively injected into the liquid chromatograph, and the chromatogram was recorded to 4 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), and the sum of each impurity peak area shall not be greater than 5 times the area of the main peak of the control solution (1.0%).

loss on drying

take this product, dry at 105°C for 2 hours, loss weight should be 3.0% ~ 4.5% (General 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.3%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 20 parts per million of heavy metal when examined by law (General rule 0821, Law II).

arsenic salt

take l.Og of this product, add 5ml of hydrochloric acid and 23ml of water to dissolve, check according to law (General rule 0822 first law), should comply with the provisions (0.0002%).

Last Update：2022-01-01 15:03:45

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Content determination

Authoritative Data Verified Data

take this product about 0.3g, precision weighing, add glacial acetic acid 20ml and acetic anhydride 20ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (O. 1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 41.50mg of C24H30N2O2. HCI.

Last Update：2022-01-01 15:03:46

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Category

Authoritative Data Verified Data

Central stimulant.

Last Update：2022-01-01 15:03:46

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 15:03:46

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Doxapram Hydrochloride Injection

Authoritative Data Verified Data

This product is a sterilized aqueous solution of doxapram hydrochloride. Containing doxapram hydrochloride (C24H30N2O2 • HCI • H20) shall be between 90.0% and 110.0% of label load.

trait

This product is colorless and clear liquid.

identification

take an appropriate amount of this product and dilute it with water to make it contain about 0.1 mg of the solution, as the test solution; Take an appropriate amount of doxapram hydrochloride control, add water to dissolve and dilute to make about 0 per 1 ml. 1 mg solution, as a control solution. According to the chromatographic conditions under the items of related substances, each lol of the test solution and the reference solution is injected into the liquid chromatograph respectively, and the chromatograms are recorded, the retention time of the main peak in the chromatogram of the test solution should be consistent with the retention time of the main peak of the control solution.
take the test solution under the content determination item, according to ultraviolet-visible spectrophotometry (General 0401), there is maximum absorption at the wavelength of 252nm, 258nm and 264nm, there is minimal absorption at wavelengths of 244Nm, 254nm and 262NM.
This product chloride identification (1) of the reaction (General 0301).

examination

the pH value should be 3.5 to 5.5 (General 0631).
appropriate amount of related substances of this product is diluted with water to prepare a solution containing 1 mg doxapram hydrochloride per 1 ml as a test solution, the determination was carried out according to the method for related substances of doxapram hydrochloride. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.2%), the sum of each impurity peak area shall not be greater than 5 times (1.0%) of the main peak area of the control solution.
bacterial endotoxin take this product, according to the law inspection (General 1143), each 1 mg doxapram hydrochloride containing endotoxin amount should be less than 1.0EU.
others should comply with the relevant provisions under injection (General 0102).

Content determination

take 5ml of this product with precision, put it in a 250ml measuring flask, dilute it to the scale with water, shake it well, and use it as a test solution, according to ultraviolet-visible spectrophotometry (General rule 0401), determine the absorbance at the wavelength of 258mn; Take appropriate amount of doxapram hydrochloride reference substance, weigh it precisely, dissolve it with water and dilute it quantitatively to make a solution containing about 0.4mg per 1 ml, measure and calculate with the same method, that's right.

specification

5ml:lOOmg

storage

light shielding, closed storage.

Last Update：2022-01-01 15:03:47

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride

Shanghai Worldyang Chemical Co.,Ltd.

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride

Doxapram Hydrochloride

CAS: 113-07-5

Molecular Formula: C24H31ClN2O2

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Names and Identifiers

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Physico-chemical Properties

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Risk and Safety

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Standard

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Trait

Authoritative Data Verified Data

melting point

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Differential diagnosis

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Exam

Authoritative Data Verified Data

acidity

clarity and color of solution

Related substances

loss on drying

ignition residue

Heavy metals

arsenic salt

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Content determination

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Category

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Storage

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Doxapram Hydrochloride Injection

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

Supplier List

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride Request for Quotation

Doxapram Hydrochloride

CAS: 113-07-5

Molecular Formula: C24H31ClN2O2

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Names and Identifiers

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Physico-chemical Properties

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Risk and Safety

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Standard

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Trait

Authoritative Data Verified Data

melting point

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Differential diagnosis

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Exam

Authoritative Data Verified Data

acidity

clarity and color of solution

Related substances

loss on drying

ignition residue

Heavy metals

arsenic salt

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Content determination

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Category

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Storage

Authoritative Data Verified Data

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride - Doxapram Hydrochloride Injection

Authoritative Data Verified Data

trait

identification

examination

Content determination

category

specification

storage

Supplier List

1-ethyl-4-(2-morpholinoethyl)-3,3-diphenylpyrrolidin-2-one monohydrochloride